Mathematical virology, virus evolution, infectivity, vaccine breakthrough and antibody resistance
• Third party YouTube about our work on SARS-CoV-2
• SARS-CoV-2 Mutation Analyzer
• SARS-CoV-2 RBD Mutations in the US.
• JunJie Wee and Guo-Wei Wei, Deep mutational scanning of SARS-CoV-2 new variants using topological deep learning and AlphaFold 3, (2024).
• JunJie Wee, Jiahui Chen, and Guo-Wei Wei, Preventing future zoonosis: SARS-CoV-2 mutations enhance human-animal cross-transmission, Computers in Biology and Medicine, 182, 109101 (2024).
• Xiaoqi Wei, Jiehui Chen and Guo-Wei Wei, Persistent topological Laplacian analysis of SARS-Cov-2 variants, Journal of Computational Biophysics and Chemistry, 22, 569-587, (2023).
• Jiahui Chen, Daniel R. Woldring, Faqing Huang, Xuefei Huang, and Guo-Wei Wei, Topological deep learning based deep mutational scanning, Computers in Biology and Medicine, 164, 107258 (2023).
• Persistent topological Laplacian analysis of SARS-Cov-2 variants, Journal of Computational Biophysics and Chemistry, 22, 569-587 (2023).
• Emerging dominant SARS-CoV-2 variants, Journal of Chemical Information and Modeling, 63, 335–342 (2022).
• Persistent Laplacian projected Omicron BA.4 and BA.5 to become new dominating variants, Computers in Biology and Medicine, 151, 106262, (2022).
• Omicron BA.2 (B.1.1.529.2): high potential to becoming the next dominating variant, The Journal of Physical Chemistry Letters, 13, 3840-3849 (2022).
• Omicron (B.1.1.529): Infectivity, vaccine breakthrough, and antibody resistance, Journal of Chemical Information and Modeling, 62 (2), 412-422 (2022).
• Artificial intelligence design of mutation-proof COVID-19 antibody therapies, Communications in Information and Systems, accepted, (2022).
• Review of the mechanisms of SARS-CoV-2 evolution and transmission, Chemical Science, (2021).
•Emerging vaccine-breakthrough SARS-CoV-2 variants,ACS Infectious Diseases,8, 3, 546–556(2022).
• Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2, Chemical Reviews, Chemical Review, 122, 13, 11287–1136 (2022).
• Mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America, The Journal of Physical Chemistry Letters, 12, 11850-11857 (2021).
• Perspective of SARS-CoV-2 main protease inhibitors, Journal of Medicinal Chemistry, 64, 16922-16955 (2021).
• Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies, Journal of Molecular Biology, 433, 167155 (2021).
• Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, South Africa, and other COVID-19-devastated countries, Genomics, 11, 2158-2170 (2021).
• UMAP-assisted K-means clustering of large-scale SARS-CoV-2 mutation datasets, Computers in Biology and Medicine, 131, 104264 (2021).
• Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies, Chemical Science, 12, 6929 - 6948 (2021).
• SARS-CoV-2 becoming more infectious as revealed by algebraic topology and deep learning, Communications in Information and Systems, 21(1), 31-36 (2021).
• Host immune response driving SARS-CoV-2 evolution, Viruses, 12, 1095 (2020).
• Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants, Communications Biology, 4, 228 (2021).
• Decoding asymptomatic COVID-19 infection and transmission, The Journal of Physical Chemistry Letters, 11, 10007-10015 (2020).
• Review of COVID-19 antibody therapies, Annual Review of Biophysics, 50, 1-30, (2021).
• Mutations strengthened SARS-CoV-2 infectivity, Journal of Molecular Biology, 432, 5212-5226 (2020).
• Mutations on COVID-19 diagnostic targets,Genomics, 112, 5204-5213 (2020).
• Repositioning of 8565 existing drugs for COVID-19, The Journal of Physical Chemistry Letters, 11, 13, 5373–5382 (2020).
• Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 92 crystal structures,Chemical Science, 11, 12036 - 12046 (2020).
• Decoding SARS-CoV-2 transmission, evolution and ramification on COVID-19 diagnosis, vaccine, and medicine, Journal of Chemical Information and Modeling, 60, 5853-5865 (2020).